mRNA modification [GO_0016556]

The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. The term ‘RNA editing’ (GO:0016547) was merged into ‘RNA modification’ (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of ‘RNA editing’.

Open mRNA modification in VFB

Term Information

  • ID: GO_0016556
  • Name: mRNA modification
  • Definition: The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.
  • Synonyms:
  • Type:
  • Comment: The term ‘RNA editing’ (GO:0016547) was merged into ‘RNA modification’ (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of ‘RNA editing’.

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0016556",
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            "short_form": "GO_0016556",
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            "label": "mRNA modification"
        },
        "description": [
            "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically."
        ],
        "comment": [
            "The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'."
        ]
    },
    "query": "Get JSON for Class",
    "version": "275438e",
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            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0009451",
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            "short_form": "GO_0009451",
            "unique_facets": [
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            "label": "RNA modification"
        },
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            "iri": "http://purl.obolibrary.org/obo/GO_0016071",
            "types": [
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                "Class",
                "has_subClass"
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            "short_form": "GO_0016071",
            "unique_facets": [
                "Class"
            ],
            "label": "mRNA metabolic process"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_narrow_synonym",
                "label": "mRNA editing",
                "type": ""
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                "PubMed": "",
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    "def_pubs": []
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