methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO_0004491]
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
ID: GO_0004491
Class
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
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Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| MMSA dehydrogenase activity | related synonym | 1.2.1.27 |
| MSDH activity | related synonym | 1.2.1.27 |
| methylmalonate-semialdehyde dehydrogenase (acylating) activity | related synonym |
References
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