L-glutamate gamma-semialdehyde dehydrogenase activity [GO_0003842]

L-glutamate gamma-semialdehyde dehydrogenase activity

ID: GO_0003842

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + 2 H+.

(S)-1-pyrroline-5-carboxylate is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. The activity can also oxidize other 1-pyrrolines, e.g. oxidation of 3-hydroxy-1-pyrroline-5-carboxylate to 4-hydroxyglutamate, and oxidation of (R)-1-pyrroline-5-carboxylate to D-glutamate.