fatty acid elongase activity [GO_0009922]

Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
Tags:

fatty acid elongase activity

ID: GO_0009922

Class

Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.

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Classification

Alternative Names

Synonym Scope Reference
condensing enzyme broad synonym
ELOVL exact synonym
very-long-chain 3-ketoacyl-CoA synthase exact synonym
very-long-chain beta-ketoacyl-CoA synthase exact synonym
very-long-chain 3-oxoacyl-CoA synthase exact synonym
elongation of very long chain fatty acids activity exact synonym