endocardial cushion [UBERON_0002062]

The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form
Tags:

Open endocardial cushion in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/UBERON_0002062",
            "symbol": "",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0002062",
            "label": "endocardial cushion"
        },
        "description": [
            "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]."
        ],
        "comment": [
            "GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form"
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0014387",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0014387",
            "label": "mesenchyme derived from neural crest"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0009751",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0009751",
            "label": "cardiac mesenchyme"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0002050",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "UBERON_0002050",
            "label": "embryonic structure"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0005256",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "UBERON_0005256",
            "label": "trunk mesenchyme"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/UBERON_0002165",
                "types": [
                    "Entity",
                    "Anatomy",
                    "Class"
                ],
                "short_form": "UBERON_0002165",
                "label": "endocardium"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "AV cushion",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "Unattributed",
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        },
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "endocardial cushions",
                "type": "http://purl.obolibrary.org/obo/uberon/core#PLURAL"
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "Unattributed",
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
    ],
    "def_pubs": []
}