nuclear receptor activity [GO_0004879]

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Tags:

nuclear receptor activity

ID: GO_0004879

Class

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.

Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.

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Classification

Relationships

Alternative Names

Synonym Scope Reference
ligand-dependent transcription factor activity related synonym bf
ligand-dependent nuclear receptor activity related synonym bf
estrogen nuclear receptor activity narrow synonym bf
glucocorticoid receptor activity narrow synonym bf
calcitriol receptor activity narrow synonym
thyroid hormone receptor activity narrow synonym
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding narrow synonym
juvenile hormone receptor activity narrow synonym
ecdysteroid hormone receptor activity narrow synonym
nuclear hormone receptor narrow synonym
retinoic acid receptor activity narrow synonym
vitamin D receptor activity narrow synonym
RXR narrow synonym
vitamin A receptor activity narrow synonym
vitamin D3 receptor activity narrow synonym bf
androgen receptor activity narrow synonym
9-cis retinoic acid receptor activity narrow synonym
1,25-(OH)2D3 receptor activity narrow synonym Calcitriol
retinoid-X receptor activity narrow synonym bf
RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding narrow synonym
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity exact synonym
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding exact synonym

References