structural_interaction_variant [SO_0002093]

structural_interaction_variant

ID: SO_0002093

A variant that impacts the internal interactions of the resulting polypeptide structure.

Requested by Pablo Cingolani. The way I calculate this is simply by looking at the PDB entry of one protein and then marking those AA that are within 3 Angstrom of each other (and far away in the AA sequence, e.g. over 20 AA distance). The assumption is that, since they are very close in distance, they must be "interacting" and thus important for protein structure.