N-terminal protein N-methyltransferase activity [GO_0071885]
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
Note
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Term Information
- ID: GO_0071885
- Name: N-terminal protein N-methyltransferase activity
- Definition: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
- Synonyms:
- Type:
- Comment:
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0071885",
"symbol": "",
"types": [
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],
"short_form": "GO_0071885",
"unique_facets": [
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"label": "N-terminal protein N-methyltransferase activity"
},
"description": [
"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "275438e",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0008757",
"types": [
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"has_subClass"
],
"short_form": "GO_0008757",
"unique_facets": [
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"label": "S-adenosylmethionine-dependent methyltransferase activity"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0008276",
"types": [
"Entity",
"Class",
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],
"short_form": "GO_0008276",
"unique_facets": [
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"label": "PRMT1 methylates ESRs"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "X-Pro-Lys N-terminal methyltransferase",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"short_form": "Unattributed",
"unique_facets": [
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"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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