I-kappaB phosphorylation [GO_0007252]
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Note
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Term Information
- ID: GO_0007252
- Name: I-kappaB phosphorylation
- Definition: The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
- Synonyms:
- Type:
- Comment:
VFB Term Json
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"short_form": "GO_0007252",
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"label": "I-kappaB phosphorylation"
},
"description": [
"The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "275438e",
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"iri": "http://purl.obolibrary.org/obo/GO_0006468",
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"label": "protein phosphorylation"
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"object": {
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"iri": "http://purl.obolibrary.org/obo/GO_0007249",
"types": [
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"short_form": "GO_0007249",
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"label": "canonical NF-kappaB signal transduction"
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"xrefs": [],
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