histone H4K20me methyltransferase activity [GO_0140941]

Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethylated lysine residue at position 20 of histone H4, producing H4K20me2.
Tags:

histone H4K20me methyltransferase activity

ID: GO_0140941

Class

Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethylated lysine residue at position 20 of histone H4, producing H4K20me2.

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

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Classification

Alternative Names

Synonym Scope Reference
histone H4-K20 dimethylation broad synonym
histone H4K20 dimethylation broad synonym
histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific) exact synonym
histone H4K20me methylase activity exact synonym