histone H3K4 dimethyltransferase activity [GO_0140946]

Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2.

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Class
GO

histone H3K4 dimethyltransferase activity

ID: GO_0140946

Class

Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2.

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

histone H3K4 methyltransferase activity

Alternative Names

Synonym	Scope	Reference
histone H3K4 dimethylation	broad synonym
histone H3-K4 dimethylation	broad synonym
histone H3K4 dimethylase activity	exact synonym
histone lysine N-dimethyltransferase activity (H3-K4 specific)	exact synonym

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