CAAX-protein geranylgeranyltransferase activity [GO_0004662]

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
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CAAX-protein geranylgeranyltransferase activity

ID: GO_0004662

Class

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.

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Classification

Alternative Names

Synonym Scope Reference
protein geranylgeranyltransferase type I related synonym 2.5.1.59
type I protein geranyl-geranyltransferase activity related synonym 2.5.1.59
GGTase-I activity exact synonym
geranylgeranyltransferase type I activity exact synonym
geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity exact synonym
GGTaseI activity exact synonym

References