apoptotic signaling pathway [GO_0097190]
The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
apoptotic signaling pathway
ID: GO_0097190
Class
The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
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Relationships
- is part of: apoptotic process
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| induction of apoptosis by extracellular signals | exact synonym | |
| apoptotic signalling pathway | exact synonym | mah |
References
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