negative regulation of gene expression [GO_0010629]
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene’s coding sequence is converted into a mature gene product (protein or RNA). This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen negative regulation of gene expression in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0010629",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0010629",
"label": "negative regulation of gene expression"
},
"description": [
"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)."
],
"comment": [
"This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0010468",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0010468",
"label": "regulation of gene expression"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0010605",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0010605",
"label": "negative regulation of macromolecule metabolic process"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002212",
"label": "negatively regulates",
"type": "negatively_regulates"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0010467",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0010467",
"label": "gene expression"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_related_synonym",
"label": "gene silencing",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
Feedback
Was this page helpful?
Glad to hear it! Please tell us how we can improve.
Sorry to hear that. Please tell us how we can improve.